i3003137
A SNP in the HBB gene on chromosome 11. Its most notable genotype is A;A: Sickle Cell Anemia
- Gene
- HBB
- Location
- Chr 115,248,232 (GRCh38)
- Highest magnitude
- 4.0Very important
- Tested on
- 23andMe
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBadSickle Cell Anemia
- A;TBadSickle Cell Anemia carrier; malaria resistance
- T;TGoodnormal
On SNPedia: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other HBB SNPs
- rs11549407A;ABeta Thalassemia major; Hemoglobin beta-zeroVery important
- rs33945777T;TBeta Thalassemia major; Hemoglobin beta-zero; possibly transfusion dependentVery important
- rs33960103G;GBeta Thalassemia major; Hemoglobin beta-zero; possibly transfusion dependentVery important
- rs33971440T;TBeta Thalassemia major; Hemoglobin beta-zero; possibly transfusion dependentVery important
- rs33974936T;TBeta Thalassemia major; Hemoglobin beta-zeroVery important
- rs33986703A;ABeta Thalassemia major; Hemoglobin beta-zero; possibly transfusion dependentVery important
- rs34716011T;TBeta Thalassemia major; Hemoglobin beta-zero; possibly transfusion dependentVery important
- rs34889882-;-Beta Thalassemia major; Hemoglobin beta-zero; possibly transfusion dependentVery important
Genosets
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Notes
Sickle Cell Anemia and Malaria Resistance See also gs228, and gs229 rs334
A;A
Sickle Cell Anemia
A;T
Bad: You are a carrier for Sickle Cell Anemia. Consider having a partner tested to understand probabilities of your potential offspring expressing Sickle Cell Anemia. Good: You are naturally resistant to malaria. Note some believe gs229 individuals should be identified by screening before being exposed to extreme physical exertion due to ~30x higher risk for sudden death; however, the risk is still rather low - 30 per 100,000 vs 1 per 100,000. see also *rs334 and gs229
References
Source and license
Adapted from i3003137 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.