i5000099

A SNP in the MT-ND4 gene on chromosome MT. Its most notable genotype is A;A: MELAS syndrome

Gene
MT-ND4
Location
Chr MT11,778 (GRCh38)
Highest magnitude
4.0Very important
Tested on
23andMe

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. -;GGoodNo summary available.Typical · 0.0
  2. A;AMost notableBadMELAS syndromeVery important · 4.0
  3. G;GGoodNo summary available.Typical · 0.0

On SNPedia: (-;G), (A;A), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other MT-ND4 SNPs

All MT-ND4 SNPs

Notes

From SNPedia

Show notes, about 140 words

rs199476112 Leber's Hereditary Optic Neuropathy (LHON) https://www.23andme.com/you/community/thread/7200/ http://LHON.org http://UMDF.org

A;A

http://en.wikipedia.org/wiki/Leber's_hereditary_optic_neuropathy Leber’s hereditary optic neuropathy (LHON) or Leber optic atrophy is a mitochondrially inherited (mother to all offspring) degeneration of retinal ganglion cells (RGCs) and their axons that leads to an acute or subacute loss of central vision; this affects predominantly young adult males. Clinically, there is an acute onset of visual loss, first in one eye, and then a few weeks to months later in the other. Onset is usually young adulthood, but age range at onset from 7-75 is reported. The age of onset is slightly higher in females (range 19–55 years: mean 31.3 years) than males (range 15–53 years: mean 24.3). http://LHON.org http://UMDF.org

Source and license

Adapted from i5000099 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.