i5007022
A SNP in the F9 gene on chromosome X. Its most notable genotype is A;G: “royal disease” also known as hemophilia B or Christmas disease
- Gene
- F9
- Location
- Chr X138,623,232 (GRCh38)
- Highest magnitude
- 8.0Very important
- Tested on
- 23andMe
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;GMost notableNot rated“royal disease” also known as hemophilia B or Christmas disease
- G;GNot rated“royal disease” also known as hemophilia B or Christmas disease
On SNPedia: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other F9 SNPs
- rs398122990A;G“royal disease” also known as hemophilia B or Christmas diseaseVery important
- rs137852229C;CHemophilia B (severity varies)Very important
- rs137852230G;GHemophilia B (severity varies)Very important
- rs137852231C;CHemophilia B (severity varies)Very important
- rs137852232G;GHemophilia B (severity varies)Very important
- rs137852233A;AHemophilia B (severity varies)Very important
- rs137852234G;GHemophilia B (severity varies)Very important
- rs137852235C;CHemophilia B (severity varies)Very important
Notes
From SNPedia
Show notes, about 160 words
rs398122990 The (G) allele represents a very rare - possibly extinct - form of Hemophilia B. See discussion at rs398122990.
A;G
You apparently carry a form of hemophilia known as the “royal disease,” transmitted from Queen Victoria (1819–1901) to European royal families. It is currently unknown if this "royal disease" rs398122990(G) SNP is extinct world-wide, but if you're seeing this in your Promethease report, you may be the proof that the variant is not extinct. Please email info@snpedia.com and let us know that you saw this in your report.
G;G
You apparently carry a form of hemophilia known as the “royal disease,” transmitted from Queen Victoria (1819–1901) to European royal families. It is currently unknown if this "royal disease" rs398122990(G) SNP is extinct world-wide, but if you're seeing this in your Promethease report, you may be the proof that the variant is not extinct. Please email info@snpedia.com to let us know that you saw this in your report.
Source and license
Adapted from i5007022 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.