i5010445
A SNP. Its most notable genotype is D;I: apparently common miscall
- Gene
- None listed
- Highest magnitude
- 1.0Minor
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (D;I), (I;I). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 140 words
As of Sept 2016, this is commonly miscalled by 23andMe with too many people being told they're heterozygous. For information about causal/pathogenic BRCA2 mutations and what they imply about the odds of developing breast cancer, please see the BRCA2 page and links from that page.
D;I
While this is apparently supposed to be a BRCA2 variant pathogenic for breast cancer, multiple people have found it in their raw data, and then had clinically validated testing done, which shows that they actually have the normal genotype. In theory this should be rs80359741, a mutation pathogenic for breast cancer, but as of Sept 2016 it appears to be just noise. See also *https://www.reddit.com/r/promethease/comments/53kxu1/confusing_test_results/ and *https://www.reddit.com/r/23andme/comments/53ay25/23andme_raw_data_accuracy_promethease_analysis/
Source and license
Adapted from i5010445 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.