i5010570(D;I)

Very likely to be a false positive (miscall) in 23andMe data; would be a BRCA2 variant pathogenic for breast cancer if it were accurate

Magnitude
6.0Very important
Repute
Bad
On SNPedia
i5010570(D;I)
Gene
None listed

Other genotypes of i5010570

    All about i5010570

    Notes

    From SNPedia

    Although named differently by 23andMe, this SNP is supposed to represent rs80359747, a BRCA2 gene mutation pathogenic for breast cancer. However (1) we see that the frequency of pathogenic genotypes reported for this mutation in Promethease reports from 23andMe users is probably at least 10 fold higher than the average pathogenic BRCA2 genotype, and (2) we've had multiple Promethease users report having this genotype in their 23andMe data, yet not replicating when validated with a clinical test. Information about one such case is visible at https://www.reddit.com/r/23andme/comments/53ay25/23andme_raw_data_accuracy_promethease_analysis/. If this genotype occurs in your Promethease report info@promethease.com would very much like to hear from you. We also suggest clinically validated testing to confirm (and we are interested in hearing the results of that too).

    Source and license

    Adapted from i5010570(D;I) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

    SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.