rs10008492

A SNP on chromosome 4. Its most notable genotype is C;C: normal

Gene
None listed
Location
Chr 438,764,099 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
26%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodnormalTypical · 0.07% of people
  2. C;TBadVery small 1.1x increased risk for Non-hodgkin's lymphomaTypical · 0.015% of people
  3. T;TBad1.4x increased risk for Non-hodgkin's lymphomaTypical · 0.079% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageC;C 7% C;T 15% T;T 79%
  • European ancestry (Utah)C;C 38% C;T 49% T;T 13%
  • Han Chinese (Beijing)C;C 0% C;T 0% T;T 100%
  • Japanese (Tokyo)C;C 0% C;T 0% T;T 100%
  • Yoruba (Nigeria)C;C 0% C;T 0% T;T 100%
  • African ancestry (Southwest US)C;C 0% C;T 16% T;T 84%
  • Chinese (Denver)C;C 0% C;T <1% T;T 99%
  • Gujarati IndianC;C 0% C;T 11% T;T 89%
  • Mexican ancestry (Los Angeles)C;C 4% C;T 23% T;T 74%
  • Maasai (Kenya)C;C 0% C;T 1% T;T 99%
  • TuscanC;C 26% C;T 45% T;T 30%

Notes

From SNPedia

Show notes, about 140 words

rs10008492 is a SNP located in a cluster of toll-like receptor genes. In a pooled analysis including three population-based case-control studies of Non-Hodgkin's lymphoma (1,946 cases, 1,808 controls), two SNPs in moderate linkage disequilibrium were significantly associated with NHL: rs10008492 (odds ratio for (C;T) genotype 1.12, CI: 0.97-1.30; OR(T;T) 1.40, CI: 1.15-1.71; p(trend)=0.001) and rs4833103 (OR(A;C) 0.75, CI: 0.64-0.88; OR(A;A) 0.74, CI: 0.62-0.90; p(trend)=0.002; p(dominant)=0.0002). The impact of divergence time on the nature of population structure: an example from Iceland. Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies. Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk.

Source and license

Adapted from rs10008492 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.