rs1001179

A SNP in the CAT gene on chromosome 11. Its most notable genotype is T;T: 0.6x decreased acoustic neuroma risk

Gene
CAT
Location
Chr 1134,438,684 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
12%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableNot rated0.6x decreased acoustic neuroma riskTypical · 0.02% of people
  2. C;TNot rated0.6x decreased acoustic neuroma riskTypical · 0.016% of people
  3. C;CNot ratednormalTypical · 0.082% of people

SNPedia records rs1001179 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 2% C;T 16% C;C 82%
  • European ancestry (Utah)T;T 4% C;T 41% C;C 56%
  • Han Chinese (Beijing)T;T 0% C;T 6% C;C 94%
  • Japanese (Tokyo)T;T 0% C;T 5% C;C 95%
  • Yoruba (Nigeria)T;T 0% C;T 2% C;C 98%
  • African ancestry (Southwest US)T;T 0% C;T 7% C;C 93%
  • Chinese (Denver)T;T <1% C;T 7% C;C 92%
  • Gujarati IndianT;T 2% C;T 35% C;C 63%
  • Luhya (Kenya)T;T <1% C;T 5% C;C 95%
  • Mexican ancestry (Los Angeles)T;T 7% C;T 26% C;C 67%
  • Maasai (Kenya)T;T 0% C;T 12% C;C 89%
  • TuscanT;T 5% C;T 32% C;C 63%

Notes

From SNPedia

Notes

A study of non-Hispanic Caucasians with various types of brain tumors concluded that there was an decreased risk of acoustic neuroma (odds ratio 0.6, CI: 0.3-1.0) associated with the rs1001179(A) allele, as oriented in dbSNP orientation (and not as published). {{PMID Auto |PMID=21795425 |Title=Genetic Variation in Myeloperoxidase Modifies the Association of Serum {alpha}-Tocopherol with Aggressive Prostate Cancer among Current Smokers |OA=1 }}

Source and license

Adapted from rs1001179 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.