rs10011796
A SNP. Its most notable genotype is C;T: Less response to allopurinol in Caucasians with gout
- Gene
- None listed
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodcommon/normal (in most populations)
- C;TMost notableBadLess response to allopurinol in Caucasians with gout
- T;TBadLess response to allopurinol in Caucasians with gout
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 150 words
rs10011796 represents a variant in the ABCG2 gene on chromosome 4. In most (but not all) populations, the minor allele is (T). It is genetically independent of rs2231142, a different ABCG2 gene variant that has been linked to gout in several populations. A 2015 GWAS study of allopurinol response reported that in non-Hispanic whites, rs10011796(T) showed the strongest statistical association. When other ethnicities were included in a meta-analysis, the association remained significant but weakened somewhat (from p = 2x10e−8 to 7x10e−4). In 2017, rs10011796 was reported to be associated with tophi development in gout patients of Western Polynesian (but not Eastern Polynesian) origin. The authors suggest that the ancestry-specific effects of ABCG2 variants may be due to haplotype backgrounds.
C;T
see text; may apply to at least some other ethnicities as well
T;T
see text; may apply to at least some other ethnicities as well
Source and license
Adapted from rs10011796 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.