rs10086908

A SNP in the LOC105375751 gene on chromosome 8. Its most notable genotype is C;C: 1.7x increased risk for prostate cancer

Gene
LOC105375751
Location
Chr 8126,999,692 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
28%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad1.7x increased risk for prostate cancerWorth knowing · 2.08% of people
  2. C;TBad1.7x increased risk for prostate cancerWorth knowing · 2.038% of people
  3. T;TGoodnormal riskTypical · 0.054% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 8% C;T 38% T;T 54%
  • European ancestry (Utah)C;C 12% C;T 48% T;T 40%
  • Han Chinese (Beijing)C;C 4% C;T 32% T;T 64%
  • Japanese (Tokyo)C;C 4% C;T 41% T;T 55%
  • Yoruba (Nigeria)C;C 3% C;T 31% T;T 67%
  • African ancestry (Southwest US)C;C 5% C;T 39% T;T 56%
  • Chinese (Denver)C;C 3% C;T 32% T;T 65%
  • Gujarati IndianC;C 4% C;T 39% T;T 57%
  • Luhya (Kenya)C;C 15% C;T 36% T;T 50%
  • Mexican ancestry (Los Angeles)C;C 19% C;T 35% T;T 47%
  • Maasai (Kenya)C;C 13% C;T 46% T;T 41%
  • TuscanC;C 9% C;T 43% T;T 48%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs10086908 is a SNP in the 8q24 chromosomal region, which has been linked in several studies to prostate cancer. In a study of 1,563 patients of European ancestry, rs10086908 was designated as the representative of a prostate cancer risk region termed "locus 3", with an odds ratio of 1.70 (CI: 1.39-2.07) for carriers of a risk genotype. Two other regions of chromosome 8q24 were also studied. Confirmation study of prostate cancer risk variants at 8q24 in African Americans identifies a novel risk locus. Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer.

Source and license

Adapted from rs10086908 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.