rs10090154
A SNP on chromosome 8. Its most notable genotype is T;T: 1.4x increased risk for prostate cancer
- Gene
- None listed
- Location
- Chr 8127,519,892 (GRCh38)
- Highest magnitude
- 2.1Worth knowing
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 13%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CNot ratednormal
- C;TBad1.4x increased risk for prostate cancer
- T;TMost notableBad1.4x increased risk for prostate cancer
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageC;C 80% C;T 16% T;T 4%
- European ancestry (Utah)C;C 89% C;T 11% T;T 0%
- Han Chinese (Beijing)C;C 86% C;T 9% T;T 5%
- Japanese (Tokyo)C;C 76% C;T 20% T;T 5%
- Yoruba (Nigeria)C;C 71% C;T 24% T;T 5%
Related
Conditions, medicines and genes
Notes
From SNPedia
Notes
rs10090154 is a SNP in chromosome 8q24 "region 1", associated with increased risk for prostate cancer. The odds ratio for the (T) risk allele were 1.42 (CI: 1.07-1.87, p=0.014), and they were not significantly different between Caucasians and African-Americans in this study of ~500 patients. In follow-up studies looking at disease severity (and not just overall risk), this SNP is reported to account for the risk (from region 1) of advanced prostate cancer. Note that a meta-analysis across 10+ studies, including over 15,000 prostate cancer cases, reported the risk for a different SNP (rs1447295) representing the same region, "region 1", of this chromosome.
Source and license
Adapted from rs10090154 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.