rs1012053

A SNP in the DGKH gene on chromosome 13. Its most notable genotype is C;C: 0.39x reduced risk of Bipolar Disorder.

Gene
DGKH
Location
Chr 1342,079,301 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
25%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ABadNormal (higher) risk of Bipolar Disorder.Minor · 1.559% of people
  2. A;CGood0.625x reduced risk of Bipolar Disorder.Worth knowing · 2.033% of people
  3. C;CMost notableGood0.39x reduced risk of Bipolar Disorder.Worth knowing · 2.18% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 59% A;C 33% C;C 8%
  • European ancestry (Utah)A;A 77% A;C 20% C;C 3%
  • Han Chinese (Beijing)A;A 28% A;C 52% C;C 20%
  • Japanese (Tokyo)A;A 20% A;C 52% C;C 28%
  • Yoruba (Nigeria)A;A 90% A;C 10% C;C <1%
  • African ancestry (Southwest US)A;A 75% A;C 25% C;C 0%
  • Chinese (Denver)A;A 32% A;C 50% C;C 19%
  • Gujarati IndianA;A 57% A;C 34% C;C 9%
  • Luhya (Kenya)A;A 80% A;C 20% C;C 0%
  • Mexican ancestry (Los Angeles)A;A 46% A;C 46% C;C 9%
  • Maasai (Kenya)A;A 74% A;C 25% C;C <1%
  • TuscanA;A 66% A;C 31% C;C 3%

Other DGKH SNPs

All DGKH SNPs

Notes

From SNPedia

Notes

Bipolar disorder failed to replicate in

A;A

This is the most common version of this SNP, so most people have this. But it is suspected of having a higher risk of Bipolar Disorder compared to the other rare versions of this SNP.

C;C

Greatly reduced risk of Bipolar I Disorder. Based on preliminary research.

Source and license

Adapted from rs1012053 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.