rs1012672

A SNP in the LRP6 gene on chromosome 12. Its most notable genotype is G;G: common in complete genomics

Gene
LRP6
Location
Chr 1212,131,981 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
4%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodcommon in complete genomicsTypical · 0.092% of people
  2. C;CNot ratedNo summary available.Typical · 0.00% of people

SNPedia records rs1012672 on the minus strand: (C;C), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 92% C;C 0%
  • European ancestry (Utah)G;G 83% C;C 0%
  • Han Chinese (Beijing)G;G 99% C;C 0%
  • Japanese (Tokyo)G;G 89% C;C 0%
  • Yoruba (Nigeria)G;G 95% C;C 0%
  • African ancestry (Southwest US)G;G 98% C;C 0%
  • Chinese (Denver)G;G 96% C;C 0%
  • Gujarati IndianG;G 94% C;C 0%
  • Luhya (Kenya)G;G 93% C;C 0%
  • Mexican ancestry (Los Angeles)G;G 90% C;C 0%
  • Maasai (Kenya)G;G 87% C;C 0%
  • TuscanG;G 86% C;C 0%

Other LRP6 SNPs

All LRP6 SNPs

Notes

From SNPedia

Notes

rs1012672 increases susceptibility to Alzheimer's disease, late-onset 1.54 times for carriers of the T allele

Source and license

Adapted from rs1012672 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.