rs1012729

A SNP in the WNK1 gene on chromosome 12. Its most notable genotype is A;A: normal

Gene
WNK1
Location
Chr 12878,316 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
29%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratednormalTypical · 0.046% of people
  2. A;GNot ratedaltered pediatric blood pressureTypical · 0.042% of people
  3. G;GGoodaltered pediatric blood pressureTypical · 0.012% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 46% A;G 42% G;G 12%
  • European ancestry (Utah)A;A 50% A;G 40% G;G 10%
  • Han Chinese (Beijing)A;A 64% A;G 31% G;G 5%
  • Japanese (Tokyo)A;A 61% A;G 37% G;G 2%
  • Yoruba (Nigeria)A;A 25% A;G 50% G;G 25%
  • African ancestry (Southwest US)A;A 30% A;G 51% G;G 19%
  • Chinese (Denver)A;A 60% A;G 36% G;G 5%
  • Gujarati IndianA;A 42% A;G 43% G;G 16%
  • Luhya (Kenya)A;A 33% A;G 47% G;G 20%
  • Mexican ancestry (Los Angeles)A;A 48% A;G 45% G;G 7%
  • Maasai (Kenya)A;A 42% A;G 46% G;G 13%
  • TuscanA;A 54% A;G 40% G;G 6%

Conditions, medicines and genes

Other WNK1 SNPs

All WNK1 SNPs

Notes

From SNPedia

Notes

rs1012729 is a SNP in the WNK lysine deficient protein kinase 1 WNK1 gene. In the Avon Longitudinal Study of Parent and Children Study (5326 subjects measured for systolic blood pressure at 11 years of age), rs1012729(G) carriers were associated with a gender-adjusted change in a diastolic blood pressure gradient of -0.11 mm Hg/y (CI: -0.20 to -0.03 mm Hg/y; p=0.0054). This variant also showed association with systolic blood pressure.

Source and license

Adapted from rs1012729 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.