rs10127939(T;T)
Immunodeficiency, but not for 23andMe users
- Magnitude
- 1.0Minor
- Repute
- Bad
- Frequency
- 93%Average of 4 populations
- On SNPedia
- rs10127939(A;A)Minus strand
- Gene
- FCGR3A
Frequency
Share of people with T;T in each HapMap population.
- Han Chinese (Beijing)100%
- Japanese (Tokyo)100%
- European ancestry (Utah)90%
- Yoruba (Nigeria)83%
Other genotypes of rs10127939
Notes
From SNPedia
For 23andMe users, this is the normal form, you can safely ignore it. However when oriented to current versions of dbSNP, this is a very rare genotype and linked to immunodeficiency This rare homozygous genotype has been reported to be the basis of primary immunodeficiency-20 in several publications. However, due to the orientation issues (and confusion) connected to A/T ambiguous flips and the assignment of this SNP to the reverse strand in dbSNP in at least some versions of dbSNP, be aware that this may be a false assignment if you see it in your Promethease report and it should be independently checked/verified.
Source and license
Adapted from rs10127939(A;A) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.