rs10134944

A SNP in the SLC35F4 gene on chromosome 14. Its most notable genotype is C;T: 1.4x risk of bipolar disorder.

Gene
SLC35F4
Location
Chr 1457,652,478 (GRCh38)
Highest magnitude
1.4Minor
Tested on
23andMe
Minor allele frequency
15%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CNot ratednormal risk of bipolar disorder.Typical · 0.070% of people
  2. C;TMost notableBad1.4x risk of bipolar disorder.Minor · 1.426% of people
  3. T;TBad1.3x risk of bipolar disorderMinor · 1.34% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageC;C 70% C;T 26% T;T 4%
  • European ancestry (Utah)C;C 84% C;T 16% T;T 0%
  • Han Chinese (Beijing)C;C 65% C;T 30% T;T 4%
  • Japanese (Tokyo)C;C 63% C;T 30% T;T 7%
  • Yoruba (Nigeria)C;C 59% C;T 40% T;T 2%
  • African ancestry (Southwest US)C;C 52% C;T 41% T;T 7%
  • Gujarati IndianC;C 73% C;T 24% T;T 3%
  • Luhya (Kenya)C;C 63% C;T 26% T;T 11%
  • Mexican ancestry (Los Angeles)C;C 83% C;T 17% T;T 0%
  • Maasai (Kenya)C;C 77% C;T 21% T;T 1%
  • TuscanC;C 81% C;T 18% T;T 1%

Conditions, medicines and genes

Other SLC35F4 SNPs

All SLC35F4 SNPs

Notes

From SNPedia

Notes

rs10134944 has been reported in a large study to be associated with bipolar disorder. The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 1.45 (CI 1.24-1.68), and for homozygotes, 1.32 (CI 0.74-2.33).

Source and license

Adapted from rs10134944 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.