rs1015362

A SNP on chromosome 20. Its most notable genotype is C;T: 2-4x higher risk of sun sensitivity if part of risk haplotype.

Gene
None listed
Location
Chr 2034,150,806 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
38%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TGoodProbably tans instead of freckles and sunburns.Minor · 1.924% of people
  2. C;TMost notableBad2-4x higher risk of sun sensitivity if part of risk haplotype.Worth knowing · 2.035% of people
  3. C;CBad2-4x higher risk of sun sensitivity if part of risk haplotype.Worth knowing · 2.041% of people

SNPedia records rs1015362 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 24% C;T 35% C;C 41%
  • European ancestry (Utah)T;T 5% C;T 43% C;C 52%
  • Han Chinese (Beijing)T;T 3% C;T 20% C;C 77%
  • Japanese (Tokyo)T;T 10% C;T 35% C;C 56%
  • Yoruba (Nigeria)T;T 71% C;T 27% C;C 2%
  • African ancestry (Southwest US)T;T 68% C;T 28% C;C 4%
  • Chinese (Denver)T;T 8% C;T 26% C;C 66%
  • Gujarati IndianT;T 2% C;T 21% C;C 77%
  • Luhya (Kenya)T;T 60% C;T 33% C;C 7%
  • Mexican ancestry (Los Angeles)T;T 10% C;T 48% C;C 41%
  • Maasai (Kenya)T;T 19% C;T 62% C;C 19%
  • TuscanT;T 9% C;T 46% C;C 45%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 210 words

rs1015362 is a SNP near the ASIP (agouti signaling protein) gene on chromosome 20. This SNP is one of a tightly-linked pair that increases the likelihood of an individual being prone to sun sensitivity, in other words, freckles and sunburn, based on a study of 6,000+ Caucasians (5,000+ Icelanders + 1,000+ Dutch). The odds ratios, presumably on a dominant basis, and at least in the largest population (Icelanders) for "freckles and burns vs. no freckles and tans" for the haplotype pair rs1015362(G) - rs4911414(T) is 3.91 (CI: 2.54-6.03) for males and 2.42 (CI: 1.52-3.86) for females, with an overall p=0.051. Based on a study by the same authors of 4,000+ skin cancer patients, this haplotype was seen to confer significant increased risk for cutaneous malignant melanoma (odds ratio 1.45, p = 1.2 x 10 -9 ) as well as basal cell carcinoma (odds ratio 1.33, p = 1.2 x 10 -6 ). Influences appearance gnxp Melanoma susceptibility variants on chromosome 20q11.22 are associated with pigmentary traits and the risk of nonmelanoma skin cancer. Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.

C;T

Increased risk of sunburns and freckles instead of tanning.

C;C

Increased risk of sunburns and freckles instead of tanning.

Source and license

Adapted from rs1015362 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.