rs10166942

A SNP in the TRPM8 gene on chromosome 2. Its most notable genotype is C;C: 0.7x lower risk for migraines

Gene
TRPM8
Location
Chr 2233,916,448 (GRCh38)
Highest magnitude
1.3Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
47%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGood0.7x lower risk for migrainesMinor · 1.340% of people
  2. C;TGood0.85x lower risk for migrainesMinor · 1.134% of people
  3. T;TGoodcommon in complete genomicsTypical · 0.026% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 40% C;T 34% T;T 26%
  • European ancestry (Utah)C;C 2% C;T 31% T;T 68%
  • Han Chinese (Beijing)C;C 41% C;T 45% T;T 15%
  • Japanese (Tokyo)C;C 31% C;T 43% T;T 26%
  • Yoruba (Nigeria)C;C 84% C;T 16% T;T <1%
  • African ancestry (Southwest US)C;C 54% C;T 37% T;T 9%
  • Chinese (Denver)C;C 46% C;T 41% T;T 13%
  • Gujarati IndianC;C 20% C;T 48% T;T 33%
  • Luhya (Kenya)C;C 87% C;T 13% T;T 0%
  • Mexican ancestry (Los Angeles)C;C 10% C;T 36% T;T 53%
  • Maasai (Kenya)C;C 58% C;T 40% T;T 1%
  • TuscanC;C 5% C;T 23% T;T 73%

Conditions, medicines and genes

Other TRPM8 SNPs

All TRPM8 SNPs

Notes

From SNPedia

Notes

rs10166942 is a SNP on ch 2q37.1 in the TRPM8 gene. A large GWAS study of over 5,000 patients with migraines and a meta-analysis concluded that this SNP was one of three influencing the condition, albeit with only slight risk changes on its own. The odds ratio for the less common rs10166942(C) allele was 0.85 (CI: 0.82 - 0.89, p = 5.5 x 10e-12).

Source and license

Adapted from rs10166942 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.