rs10210302

A SNP in the ATG16L1 gene on chromosome 2. Its most notable genotype is T;T: 1.8x increased risk for Crohn's disease

Gene
ATG16L1
Location
Chr 2233,250,193 (GRCh38)
Highest magnitude
1.8Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
39%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon/normalTypical · 0.045% of people
  2. C;TBad1.2x increased risk for Crohn's diseaseMinor · 1.242% of people
  3. T;TMost notableBad1.8x increased risk for Crohn's diseaseMinor · 1.813% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 45% C;T 42% T;T 13%
  • European ancestry (Utah)C;C 15% C;T 54% T;T 31%
  • Han Chinese (Beijing)C;C 42% C;T 45% T;T 14%
  • Japanese (Tokyo)C;C 59% C;T 37% T;T 4%
  • Yoruba (Nigeria)C;C 55% C;T 36% T;T 9%
  • African ancestry (Southwest US)C;C 54% C;T 40% T;T 5%
  • Chinese (Denver)C;C 58% C;T 37% T;T 6%
  • Gujarati IndianC;C 29% C;T 48% T;T 24%
  • Luhya (Kenya)C;C 64% C;T 29% T;T 7%
  • Mexican ancestry (Los Angeles)C;C 50% C;T 36% T;T 14%
  • Maasai (Kenya)C;C 52% C;T 44% T;T 5%
  • TuscanC;C 15% C;T 60% T;T 26%

Conditions, medicines and genes

Other ATG16L1 SNPs

All ATG16L1 SNPs

Notes

From SNPedia

Notes

rs10210302 has been reported in a large study to be associated with Crohn's disease. The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 1.19 (CI 1.01-1.41), and for homozygotes, 1.85 (CI 1.56-2.21).

Source and license

Adapted from rs10210302 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.