rs10250779

A SNP in the PGAM2 gene on chromosome 7. Its most notable genotype is A;A: possible exercise-inducing cramping in African-Americans

Gene
PGAM2
Location
Chr 744,065,297 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
<1%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CGoodcommon in clinvarTypical · 0.0100% of people
  2. A;AMost notableBadpossible exercise-inducing cramping in African-AmericansWorth knowing · 2.00% of people

SNPedia records rs10250779 on the minus strand: (G;G), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 100% A;A 0%
  • European ancestry (Utah)C;C 100% A;A 0%
  • Han Chinese (Beijing)C;C 100% A;A 0%
  • Japanese (Tokyo)C;C 100% A;A 0%
  • Yoruba (Nigeria)C;C 100% A;A 0%

Notes

From SNPedia

Notes

Several African-American rs10250779(T;T) homozygotes (as oriented in dbSNP) have been reported to experience intense muscle pain and cramps upon exercising. It is not known what percentage of such homozgyotes respond to exercise in this manner. Distribution and effects of nonsense polymorphisms in human genes.

A;A

The symptoms reported (over 30 years ago) were myalgia and cramping upon exercising for several African-Americans carrying this genotype, and the disease is specifically reported as glycogen storage disease X. If you carry this genotype and certainly do not experience significant exercise-induced cramping, let us know and we will annotate this record.

Source and license

Adapted from rs10250779 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.