rs1027557

A SNP on chromosome 12. Its most notable genotype is C;T: heterozygosity seems common

Gene
None listed
Location
Chr 12130,120,384 (GRCh38)
Highest magnitude
0.1Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
29%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TNot ratedNo summary available.Typical · 0.046% of people
  2. C;TMost notableNot ratedheterozygosity seems commonTypical · 0.143% of people

SNPedia records rs1027557 on the minus strand: (A;A), (A;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 46% C;T 43%
  • European ancestry (Utah)T;T 56% C;T 41%
  • Han Chinese (Beijing)T;T 49% C;T 39%
  • Japanese (Tokyo)T;T 43% C;T 48%
  • Yoruba (Nigeria)T;T 32% C;T 53%
  • African ancestry (Southwest US)T;T 49% C;T 35%
  • Chinese (Denver)T;T 51% C;T 45%
  • Gujarati IndianT;T 57% C;T 35%
  • Luhya (Kenya)T;T 31% C;T 55%
  • Mexican ancestry (Los Angeles)T;T 53% C;T 40%
  • Maasai (Kenya)T;T 26% C;T 49%
  • TuscanT;T 60% C;T 37%

Notes

From SNPedia

Notes

This SNP, rs1027557, was mentioned as one of the SNPs defining a haplotype used during a search for a deafness-associated gene on chromosome 12. However, rs1027557 itself has no reported associations with deafness (or any other condition).

Source and license

Adapted from rs1027557 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.