rs10306114

A SNP in the PTGS1 gene on chromosome 9. Its most notable genotype is A;G: Higher risk of bleeding during coronary angiography?

Gene
PTGS1
Location
Chr 9122,370,243 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
6%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodnormalTypical · 0.0
  2. A;GMost notableBadHigher risk of bleeding during coronary angiography?Minor · 1.0
  3. G;GBadHigher risk of bleeding during coronary angiography?Minor · 1.0

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other PTGS1 SNPs

All PTGS1 SNPs

Notes

From SNPedia

Show notes, about 190 words

rs10306114, also known as -842A>G, is a SNP upstream of the cyclooxygenase-1 PTGS1 gene. A study of 696 European patients undergoing elective diagnostic coronary angiographies (CAGs) because of suspected or proven stable coronary artery disease found that 23 experienced bleeding, perhaps the most common complication of this type of invasive coronary procedure. None of the eight SNPs tested, including this SNP, were found to be associated with bleeding in the study group, as tested with common confounders controlled. In the subpopulation of low-risk bleeders with no ongoing clopidogrel treatment and no subsequential PCI operation, this SNP rs10306114 and a co-inherited SNP rs3842787 were statistically associated with bleeding: Again, eight SNPs tested, and for these two with rs10306114(G) and/or rs3842787(T) the increase in bleeding risk is OR=1.94-75.75 (95%) with expected value 12.1, p = 0.012). The confidence interval is wide indicating a small number of positives in the subpopulation, maybe one or two, and the paper had more than sixteen tests with no adjustment of p-values, which makes the test non-definitive (hence small magnitude).

Source and license

Adapted from rs10306114 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.