rs1031681

A SNP on chromosome 12. Its most notable genotype is T;T: 1.3x increased risk for depression (for those under 55)

Gene
None listed
Location
Chr 1284,526,555 (GRCh38)
Highest magnitude
1.3Minor
Tested on
AncestryDNA
Minor allele frequency
43%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableNot rated1.3x increased risk for depression (for those under 55)Minor · 1.321% of people
  2. C;TNot ratedNo summary available.Typical · 0.045% of people
  3. C;CNot ratednormalTypical · 0.033% of people

SNPedia records rs1031681 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 9 HapMap populations.

  • AverageT;T 21% C;T 45% C;C 33%
  • European ancestry (Utah)T;T 17% C;T 47% C;C 36%
  • Han Chinese (Beijing)T;T 10% C;T 39% C;C 52%
  • Japanese (Tokyo)T;T 4% C;T 26% C;C 70%
  • Yoruba (Nigeria)T;T 27% C;T 49% C;C 24%
  • African ancestry (Southwest US)T;T 25% C;T 57% C;C 18%
  • Chinese (Denver)T;T 5% C;T 41% C;C 54%
  • Gujarati IndianT;T 33% C;T 50% C;C 17%
  • Mexican ancestry (Los Angeles)T;T 31% C;T 53% C;C 16%
  • Maasai (Kenya)T;T 40% C;T 48% C;C 13%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs1031681 is one of two linked SNPs potentially associated (at a distance though) with the SLC6A15 gene; the other is rs1545843. A GWAS study and meta-analysis ultimately including six independent samples, primarily Caucasion/European but also including an African-American sample, found that the rs1031681(A) allele was associated with higher risk for major depression, but only in individuals less than 55 years old and only when homozygous, with an odds ratio of 1.3 (p = 5 x 10e-5).

Source and license

Adapted from rs1031681 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.