rs1042580
A SNP in the THBD gene on chromosome 20. Its most notable genotype is T;T: common in clinvar
- Gene
- THBD
- Location
- Chr 2023,046,984 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 28%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs1042580 on the minus strand: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 55%
- European ancestry (Utah)T;T 42%
- Han Chinese (Beijing)T;T 62%
- Japanese (Tokyo)T;T 68%
- Yoruba (Nigeria)T;T 66%
- African ancestry (Southwest US)T;T 74%
- Chinese (Denver)T;T 73%
- Gujarati IndianT;T 33%
- Luhya (Kenya)T;T 56%
- Mexican ancestry (Los Angeles)T;T 45%
- Maasai (Kenya)T;T 41%
- TuscanT;T 45%
Related
Notes
From SNPedia
Notes
linked to Cardiovascular Events Several CVD risk variants were identified: In women, the combination of F5 rs7542281 × THBD rs1042580, together with three single F5 SNPs, was associated with CVD events. Among men, PROC rs1041296, when combined with either ICAM1 rs5030341 or F5 rs2269648, was associated with total mortality. As a single variant, PROC rs1401296, together with the F5 Leiden mutation, was associated with ischemic stroke events.
Source and license
Adapted from rs1042580 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.