rs10427255

A SNP on chromosome 2. Its most notable genotype is C;C: highest odds of photic sneeze reflex

Gene
None listed
Location
Chr 2145,367,955 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
44%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadhighest odds of photic sneeze reflexWorth knowing · 2.120% of people
  2. T;TGoodlowest odds of photic sneeze reflexTypical · 0.034% of people

On SNPedia: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 20% T;T 34%
  • European ancestry (Utah)C;C 24% T;T 29%
  • Han Chinese (Beijing)C;C 22% T;T 26%
  • Japanese (Tokyo)C;C 19% T;T 28%
  • Yoruba (Nigeria)C;C 16% T;T 36%
  • African ancestry (Southwest US)C;C 14% T;T 35%
  • Chinese (Denver)C;C 23% T;T 28%
  • Gujarati IndianC;C 30% T;T 27%
  • Luhya (Kenya)C;C 13% T;T 42%
  • Mexican ancestry (Los Angeles)C;C 11% T;T 47%
  • Maasai (Kenya)C;C 16% T;T 42%
  • TuscanC;C 32% T;T 36%

Conditions, medicines and genes

Notes

From SNPedia

Notes

For photic sneeze reflex, we find a novel association with rs10427255 (score 10.9 and an OR of 1.32). We also find a suggestive association with rs11856995 (score 7.13 and OR of 0.78). The C allele appears to be associated with higher odds of photic sneezing.

Source and license

Adapted from rs10427255 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.