rs10446073
A SNP in the CHODL gene on chromosome 21. Its most notable genotype is G;G.
- Gene
- CHODL
- Location
- Chr 2117,820,455 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 5%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 88%
- European ancestry (Utah)G;G 88%
- Han Chinese (Beijing)G;G 96%
- Japanese (Tokyo)G;G 94%
- Yoruba (Nigeria)G;G 82%
- African ancestry (Southwest US)G;G 77%
- Chinese (Denver)G;G 96%
- Gujarati IndianG;G 91%
- Luhya (Kenya)G;G 81%
- Mexican ancestry (Los Angeles)G;G 86%
- Maasai (Kenya)G;G 80%
- TuscanG;G 97%
Notes
From SNPedia
Notes
http://jid.oxfordjournals.org/content/204/11/1654.long This analysis revealed a strong association between the frequently affected phenotype and the C allele of SNP rs1062202 (?2 = 8.0, P = .0047), predicted to lie in the 3? UTR of C21orf91 (Figure 2, Table 1). Another SNP, rs10446073, which was approximately 1 kb upstream of the start site of transcription of C21orf91, also showed a moderate association (?2 = 3.57, P = .06) with the cold-sore phenotype.
Source and license
Adapted from rs10446073 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.