rs10455872

A SNP in the LPA gene on chromosome 6. Its most notable genotype is G;G: 2,57x increased Coronary Heart disease risk

Gene
LPA
Location
Chr 6160,589,086 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
3%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodcommon/normalTypical · 0.097% of people
  2. A;GBad1,51x increased Coronary Heart disease riskWorth knowing · 2.03% of people
  3. G;GMost notableBad2,57x increased Coronary Heart disease riskImportant · 3.0<1% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 97% A;G 3% G;G <1%
  • European ancestry (Utah)A;A 86% A;G 12% G;G 2%
  • Han Chinese (Beijing)A;A 100% A;G 0% G;G 0%
  • Japanese (Tokyo)A;A 100% A;G 0% G;G 0%
  • Yoruba (Nigeria)A;A 100% A;G 0% G;G 0%

Other LPA SNPs

All LPA SNPs

Notes

From SNPedia

Show notes, about 130 words

rs10455872, was associated with about 1.5-fold increased risk of Coronary Heart Disease. celera Genetic variation in LPAL2, LPA, and PLG predicts plasma lipoprotein(a) level and carotid artery disease risk. Lipoprotein(a) genetic variants associated with coronary and peripheral vascular disease but not with stroke risk in the Heart Protection Study. Single-nucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp(a) levels in African Americans. Variation in LPA is associated with Lp(a) levels in three populations from the Third National Health and Nutrition Examination Survey. Cost-effectiveness model of use of genetic testing as an aid in assessing the likely benefit of aspirin therapy for primary prevention of cardiovascular disease.

Source and license

Adapted from rs10455872 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.