rs1046089

A SNP in the PRRC2A gene on chromosome 6. Its most notable genotype is A;A: normal

Gene
PRRC2A
Location
Chr 631,635,190 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
39%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratednormalTypical · 0.018% of people
  2. A;GNot ratednormalTypical · 0.045% of people
  3. G;GGood0.48x risk of malariaTypical · 0.038% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 18% A;G 45% G;G 38%
  • European ancestry (Utah)A;A 9% A;G 43% G;G 49%
  • Han Chinese (Beijing)A;A 15% A;G 53% G;G 32%
  • Japanese (Tokyo)A;A 13% A;G 43% G;G 44%
  • Yoruba (Nigeria)A;A 40% A;G 40% G;G 20%
  • African ancestry (Southwest US)A;A 32% A;G 47% G;G 21%
  • Chinese (Denver)A;A 17% A;G 45% G;G 38%
  • Gujarati IndianA;A 6% A;G 38% G;G 56%
  • Luhya (Kenya)A;A 30% A;G 44% G;G 26%
  • Mexican ancestry (Los Angeles)A;A 9% A;G 42% G;G 49%
  • Maasai (Kenya)A;A 21% A;G 46% G;G 33%
  • TuscanA;A 7% A;G 49% G;G 44%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs1046089 is a SNP in the HLA-B associated transcript 2 BAT2 gene. A study of 2,162 case-controls found an association between rs1046089 and severe malaria.

Source and license

Adapted from rs1046089 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.