rs10490770

A SNP. Its most notable genotype is C;C: For Caucasians (only), likely higher respiratory failure odds among COVID-19 patients

Gene
None listed
Highest magnitude
3.0Important
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TGoodcommon/normalTypical · 0.0
  2. C;TBadFor Caucasians (only), likely higher respiratory failure odds among COVID-19 patientsMinor · 1.7
  3. C;CMost notableBadFor Caucasians (only), likely higher respiratory failure odds among COVID-19 patientsImportant · 3.0

SNPedia records rs10490770 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Notes

From SNPedia

Show notes, about 130 words

This SNP is primarily of interest as a proxy (i.e. substitute) for rs11385942, a SNP reported in an 2020 study to be associated with higher susceptibility to respiratory failure among COVID-19 patients. The minor allele of both SNPs is associated with somewhat higher risk; see rs11385942 for details. Note that rs10490770 is defined in dbSNP on the reverse (minus) strand. Therefore, as reported in the raw data from direct-to-consumer genotyping companies such as Ancestry or MyHeritage, the major/common ("good") allele for rs10490770 is 'T', and the minor/risk allele is 'C'. In SNPedia, those alleles are reported in accordance with the original orientation in dbSNP, and are therefore 'A' and 'G', respectively.

C;T

see text via main rs-page

C;C

see text via main rs-page

Source and license

Adapted from rs10490770 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.