rs10492519

A SNP in the FAM124A gene on chromosome 13. Its most notable genotype is G;G: Increased risk of developing prostate cancer

Gene
FAM124A
Location
Chr 1351,250,192 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
21%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodNormal risk of developing prostate cancerMinor · 1.076% of people
  2. A;GBadSlightly increased risk of developing prostate cancerMinor · 1.519% of people
  3. G;GMost notableBadIncreased risk of developing prostate cancerWorth knowing · 2.05% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 76% A;G 19% G;G 5%
  • European ancestry (Utah)A;A 29% A;G 46% G;G 25%
  • Han Chinese (Beijing)A;A 96% A;G 4% G;G 0%
  • Japanese (Tokyo)A;A 97% A;G 4% G;G 0%
  • Yoruba (Nigeria)A;A 100% A;G 0% G;G 0%
  • African ancestry (Southwest US)A;A 93% A;G 7% G;G 0%
  • Chinese (Denver)A;A 99% A;G <1% G;G 0%
  • Gujarati IndianA;A 52% A;G 44% G;G 5%
  • Luhya (Kenya)A;A 99% A;G <1% G;G 0%
  • Mexican ancestry (Los Angeles)A;A 41% A;G 45% G;G 14%
  • Maasai (Kenya)A;A 96% A;G 4% G;G 0%
  • TuscanA;A 35% A;G 54% G;G 11%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs10492519 is one of seven SNPs found in a combined study of over 1,000 patients to be associated with increased risk for prostate cancer. The risk allele for this SNP is (G); and while the odds ratio was not specifically reported, the probability of false significance (not permuted though) was given as p=5.6 x 10e-6, using an additive model of risk.

Source and license

Adapted from rs10492519 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.