rs1049331
A SNP in the HTRA1 gene on chromosome 10. Its most notable genotype is C;C: common in clinvar
- Gene
- HTRA1
- Location
- Chr 10122,461,754 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- Not on consumer chips
- Minor allele frequency
- 29%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Notes
From SNPedia
Notes
*rs11200638 1.7x10-14 (-625G>A)is the most significant associated SNP with a high OR of 7.6 (95%CI: 3.94-14.51) *rs2672598 3.0x10-10 (-487T>C) *rs1049331 3.7x10-12 (102C>T, Ala34Ala) *rs2293870 3.7x10-12 (108G>T, Gly36Gly) *haplotype ACCTT, significantly predisposes to AMD (p= 6.68x10-14) *smoking and rs800292 (184G>A, Val62Ile) of CFH. *The combined OR for disease of smoking and rs11200638 (HTRA1) caused a 15.7 fold increased risk *The combined OR for rs800292 and rs11200638 showed a 23.3 fold increased risk *An extremely high population attributable risk (PAR) of 78% was also found.
Source and license
Adapted from rs1049331 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.