rs10495584

A SNP in the LPIN1 gene on chromosome 2. Its most notable genotype is G;G: Lowers men's blood pressure by -6.3/-3.8 mm Hg.

Gene
LPIN1
Location
Chr 211,819,857 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe
Minor allele frequency
8%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratedNormal (higher) blood pressure.Minor · 1.178% of people
  2. A;GGoodLowers men's blood pressure by -6.3/-3.8 mm Hg.Worth knowing · 2.020% of people
  3. G;GMost notableGoodLowers men's blood pressure by -6.3/-3.8 mm Hg.Worth knowing · 2.52% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 78% A;G 20% G;G 2%
  • European ancestry (Utah)A;A 100% A;G 0% G;G 0%
  • Han Chinese (Beijing)A;A 58% A;G 38% G;G 4%
  • Japanese (Tokyo)A;A 77% A;G 23% G;G 0%
  • Yoruba (Nigeria)A;A 76% A;G 21% G;G 3%

Conditions, medicines and genes

Other LPIN1 SNPs

All LPIN1 SNPs

Notes

From SNPedia

Show notes, about 180 words

The minor (G) allele of SNP rs10495584 was associated with lower mean systolic and diastolic blood pressures in men (121.1 +/- 14.2 and 76.3 +/- 10.2 mm Hg vs. 127.4 +/- 15.2 and 80.1 +/- 10.5 mm Hg, P = 0.002 and 0.007, respectively), but not in women (P > 0.05), and remained significant after correction for numerous other factors. However, its effect may be caused by a nearby, tightly linked SNP, rs11524.

A;A

Almost all white people and a majority of non-white people have this normal version. But it isn't as good as the other rare mutant version which would have lowered blood pressure. Tested in Asians. They had an average blood pressure of 127.4/80.1 with this Allele.

A;G

Rare in white people. Tested in Asians. They had an average blood pressure of 121.1/76.3 mm Hg with this Allele. However, its effect may be caused by a nearby, tightly linked SNP, rs11524.

G;G

Rare in white people. Tested in Asians. They had an average blood pressure of 121.1/76.3 mm Hg with this Allele. However, its effect may be caused by a nearby, tightly linked SNP, rs11524.

References

Source and license

Adapted from rs10495584 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.