rs10503669

A SNP on chromosome 8. Its most notable genotype is A;A: associated with higher HDL cholesterol

Gene
None listed
Location
Chr 819,990,179 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
9%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodassociated with higher HDL cholesterolWorth knowing · 2.0<1% of people
  2. A;CGoodassociated with higher HDL cholesterolWorth knowing · 2.014% of people
  3. C;CGoodNo summary available.Typical · 0.085% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A <1% A;C 14% C;C 85%
  • European ancestry (Utah)A;A 4% A;C 16% C;C 81%
  • Han Chinese (Beijing)A;A <1% A;C 18% C;C 82%
  • Japanese (Tokyo)A;A <1% A;C 18% C;C 81%
  • Yoruba (Nigeria)A;A 0% A;C 8% C;C 93%
  • African ancestry (Southwest US)A;A 0% A;C 14% C;C 86%
  • Chinese (Denver)A;A <1% A;C 22% C;C 77%
  • Gujarati IndianA;A 0% A;C 18% C;C 82%
  • Luhya (Kenya)A;A <1% A;C 5% C;C 95%
  • Mexican ancestry (Los Angeles)A;A 0% A;C 10% C;C 90%
  • Maasai (Kenya)A;A 0% A;C 8% C;C 92%
  • TuscanA;A 3% A;C 19% C;C 78%

Conditions, medicines and genes

Notes

From SNPedia

Notes

Repeatedly associated with elevated lipids according to A allele is associated with 2.09mg/dl increase in HDL cholesterol (good cholesterol).

Source and license

Adapted from rs10503669 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.