rs1050450

. Published 2013. this article discussed the SNP risk for osteoarthritis in a selenium-deficient region, following up on the 2010 study also cited here. "Kashin-Beck disease (KBD) is a kind of degenerative osteoarthropathy." It found that "Haplotypes TCC, TTC and TTT of rs1050450, rs1800668 and rs3811699 in GPX1 showed a significant association with KBD and controls with P value of 0.0421, 5.0E-4 and 0.0066, respectively." (Abstract) . Published 2010, this article discussed the SNP risk for osteoarthritis in a selenium-deficient region. "Kashin-Beck disease (KBD) is a disabling osteoarthropathy involving growth cartilage endemic to selenium (Se)-deficient regions in China." "Four polymorphisms including GPX1 (rs1050450), TrxR2 (rs5748469), SEPP1 (rs7579) and DIO2 (rs225014) were analyzed for 161 KBD patients and 312 controls." However, Only GPX1 (rs1050450) polymorphisms that were heterozygote proline/leucine or homozygote leucene/leucene conferred a risk compared with the other variant: "odds ratio=1.781; 95% confidence interval: 1.127-2.814." "No association was observed between the other three single nucleotide polymorphisms (SNPs) and KBD risk." . Published 2009. {{PMID Auto |PMID=21795425 |Title=Genetic Variation in Myeloperoxidase Modifies the Association of Serum {alpha}-Tocopherol with Aggressive Prostate Cancer among Current Smokers |OA=1 }} GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer. Gene x Gene interaction between MnSOD and GPX-1 and breast cancer risk: a nested case-control study. Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography. Do genetic factors protect for early onset lung cancer? A case control study before the age of 50 years. A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk. Oxidative response gene polymorphisms and risk of adult brain tumors. The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old. Lack of association of GPX1 and MnSOD genes with symptom severity and response to clozapine treatment in schizophrenia subjects. Extent of differential allelic expression of candidate breast cancer genes is similar in blood and breast. Gene polymorphisms against DNA damage induced by hydrogen peroxide in leukocytes of healthy humans through comet assay: a quasi-experimental study. Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men. Genetic polymorphisms in antioxidative enzymes are associated to forced expiratory volume in 1 s (FEV1) in smokers independently of asthma. GPx-1 polymorphism (rs1050450) contributes to tumor susceptibility: evidence from meta-analysis. Serum selenium and single-nucleotide polymorphisms in genes for selenoproteins: relationship to markers of oxidative stress in men from Auckland, New Zealand. Antioxidant enzyme polymorphisms and neuropsychological outcomes in medulloblastoma survivors: a report from the Childhood Cancer Survivor Study.

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see text at rs1050450

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see text at rs1050450