rs10509305

A SNP in the STOX1 gene on chromosome 10. Its most notable genotype is C;C: fetuses with this genotype may cause maternal pre-eclampsia

Gene
STOX1
Location
Chr 1068,885,620 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
14%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodcommon in clinvarTypical · 0.075% of people
  2. A;CBadcarrier for pre-eclampsia associated variantMinor · 1.523% of people
  3. C;CMost notableBadfetuses with this genotype may cause maternal pre-eclampsiaImportant · 3.02% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 75% A;C 23% C;C 2%
  • European ancestry (Utah)A;A 56% A;C 39% C;C 5%
  • Han Chinese (Beijing)A;A 88% A;C 10% C;C 2%
  • Japanese (Tokyo)A;A 63% A;C 35% C;C 2%
  • Yoruba (Nigeria)A;A 97% A;C 3% C;C 0%
  • African ancestry (Southwest US)A;A 91% A;C 7% C;C 2%
  • Chinese (Denver)A;A 84% A;C 17% C;C 0%
  • Gujarati IndianA;A 61% A;C 35% C;C 4%
  • Luhya (Kenya)A;A 96% A;C 5% C;C 0%
  • Mexican ancestry (Los Angeles)A;A 43% A;C 50% C;C 7%
  • Maasai (Kenya)A;A 82% A;C 18% C;C 0%
  • TuscanA;A 62% A;C 35% C;C 3%

Conditions, medicines and genes

Other STOX1 SNPs

All STOX1 SNPs

Notes

From SNPedia

Notes

rs10509305, also known as Glu608Asp or E608D, is a variant in the storkhead box 1 STOX1 gene. In and subsequent publications, it is reported that when fetuses are rs10509305(C;C), their mothers are likely to have pre-eclampsia and possibly also pregnancy-induced hypertension.

A;C

See the rs10509305 SNPedia page for discussion. This genotype represents a carrier for a variant that, if inherited in two copies by a fetus, is associated with causing pre-eclampsia in the mother.

C;C

Fetuses inheriting two copies of rs10509305(C) are reported to cause pre-eclampsia during their (mother's) pregnancy. There may also be a tendency towards pregnancy-induced hypertension.

Source and license

Adapted from rs10509305 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.