rs1051266

A SNP in the SLC19A1 gene on chromosome 21. Its most notable genotype is T;T: common in clinvar

Gene
SLC19A1
Location
Chr 2145,537,880 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
49%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableGoodcommon in clinvarTypical · 0.029% of people

SNPedia records rs1051266 on the minus strand: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 29%
  • European ancestry (Utah)T;T 16%
  • Han Chinese (Beijing)T;T 25%
  • Japanese (Tokyo)T;T 30%
  • Yoruba (Nigeria)T;T 49%
  • African ancestry (Southwest US)T;T 21%
  • Chinese (Denver)T;T 18%
  • Gujarati IndianT;T 13%
  • Luhya (Kenya)T;T 55%
  • Mexican ancestry (Los Angeles)T;T 17%
  • Maasai (Kenya)T;T 60%
  • TuscanT;T 20%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs1051266 (Arg27Cys, 80G>A) is a snp within SLC19A1 (Solute carrier family 19 (folate transporter), member 1). Cys (A) allele associated with reduced plasma folate women with GA and AA genotypes had higher red blood cell folate concentrations, not significantly associated with serum folate or homocysteine levels methotrexate (antifolate drug) uptake lowest in individuals with GG genotype than those with GA or AA genotypes

Source and license

Adapted from rs1051266 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.