rs10513025
A SNP on chromosome 5. Its most notable genotype is C;C: >0.55x reduced risk for autism
- Gene
- None listed
- Location
- Chr 59,623,510 (GRCh38)
- Highest magnitude
- 2.1Worth knowing
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 5%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableGood>0.55x reduced risk for autism
- C;TGood0.55x reduced risk for autism
- T;TBadnormal risk of Autism
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C <1% C;T 11% T;T 89%
- European ancestry (Utah)C;C <1% C;T 7% T;T 92%
- Han Chinese (Beijing)C;C 0% C;T <1% T;T 99%
- Japanese (Tokyo)C;C 0% C;T 0% T;T 100%
- Yoruba (Nigeria)C;C 1% C;T 22% T;T 77%
- African ancestry (Southwest US)C;C 0% C;T 14% T;T 86%
- Chinese (Denver)C;C 0% C;T <1% T;T 99%
- Gujarati IndianC;C 0% C;T 5% T;T 95%
- Luhya (Kenya)C;C 3% C;T 20% T;T 77%
- Mexican ancestry (Los Angeles)C;C 0% C;T 10% T;T 90%
- Maasai (Kenya)C;C 2% C;T 24% T;T 74%
- TuscanC;C 0% C;T 15% T;T 85%
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 190 words
rs10513025 is a SNP located in chromosomal region 5p15, in between the SEMA5A and TAS2R1 genes. Based on a linkage and association mapping study of 1,031 multiplex autism families, rs10513025 was found to be associated with autism, and the expression of SEMA5A was seen to be reduced in brains from autistic patients. Although this finding was replicated, the authors caution that this SNP explains a very small fraction of the heritability of a complex disorder like autism, presumably due to their finding that the most common allele (present at a frequency of ~96%) is the allele associated with higher risk. The much rarer allele, rs10513025(C), is associated with a 0.55x reduced risk for autism (p=9.6x10e-6).
C;C
You have two copies of a rare mutation that halves (or better) your risk of Autism.
C;T
You have one copy of a rare mutation that almost halves your risk of autism.
T;T
Like almost everyone else, you have the normal version of this SNP - you didn't get the rare alternative mutations that would halve your risk of autism. Your normal version (T;T) seems to reduce the expression of SEMA5A in the brains of people with autism.
Source and license
Adapted from rs10513025 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.