rs10515860

A SNP in the HMMR gene on chromosome 5. Its most notable genotype is G;G: common in complete genomics

Gene
HMMR
Location
Chr 5163,490,702 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
7%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodcommon in complete genomicsTypical · 0.088% of people

On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageG;G 88%
  • European ancestry (Utah)G;G 73%
  • Han Chinese (Beijing)G;G 93%
  • Japanese (Tokyo)G;G 94%
  • Yoruba (Nigeria)G;G 100%
  • African ancestry (Southwest US)G;G 91%
  • Chinese (Denver)G;G 87%
  • Gujarati IndianG;G 74%
  • Mexican ancestry (Los Angeles)G;G 79%
  • Maasai (Kenya)G;G 98%
  • TuscanG;G 85%

Conditions, medicines and genes

Other HMMR SNPs

All HMMR SNPs

Notes

From SNPedia

Show notes, about 150 words

cancergenetics The risk of breast cancer was 23% higher in women who had one copy of genetic variant (the A-C-A haplotype: rs7712023-rs299290-rs10515860), and 46% higher in women with two copies. In addition, those women were diagnosed an average of 12 months younger than women from the control group, suggesting that HMMR is linked to early-onset breast cancer. However, a more recent, larger European case-control study found no association between rs10515860 and risk of breast cancer. breast cancer *rs10515860 [odds ratio (OR; AA/GG), 0.85; 95% confidence interval (CI), 0.65-1.12; P(trend) = 0.9], *rs299290 [OR (CC/TT), 1.00; 95% CI, 0.87-1.15; P(trend) = 0.7], *rs3756648 (rs7712023) [OR (TT/CC), 0.93; 95% CI, 0.84-1.02; P(trend) = 0.1], *rs299284 [OR (TT/CC), 1.01; 95% CI, 0.76-1.35; P(trend) = 0.5], and *rs13183712 [OR (TT/GG), 1.04; 95% CI, 0.88-1.23; P(trend) = 0.6].

Source and license

Adapted from rs10515860 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.