rs10516487

A SNP in the BANK1 gene on chromosome 4. Its most notable genotype is A;A: slightly higher risk for lupus

Gene
BANK1
Location
Chr 4101,829,919 (GRCh38)
Highest magnitude
1.4Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
22%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodcommon in clinvarTypical · 0.063% of people
  2. A;GBadslightly higher risk for lupusMinor · 1.233% of people
  3. A;AMost notableBadslightly higher risk for lupusMinor · 1.44% of people

SNPedia records rs10516487 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 63% A;G 33% A;A 4%
  • European ancestry (Utah)G;G 55% A;G 40% A;A 5%
  • Han Chinese (Beijing)G;G 69% A;G 30% A;A 2%
  • Japanese (Tokyo)G;G 78% A;G 21% A;A <1%
  • Yoruba (Nigeria)G;G 55% A;G 40% A;A 5%
  • African ancestry (Southwest US)G;G 68% A;G 30% A;A 2%
  • Chinese (Denver)G;G 75% A;G 25% A;A 0%
  • Gujarati IndianG;G 61% A;G 31% A;A 8%
  • Luhya (Kenya)G;G 60% A;G 38% A;A 3%
  • Mexican ancestry (Los Angeles)G;G 78% A;G 22% A;A 0%
  • Maasai (Kenya)G;G 41% A;G 49% A;A 10%
  • TuscanG;G 50% A;G 42% A;A 8%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs17266594 rs10516487 rs3733197 gene associated with systemic lupus erythematosus. The association between rs10516487 and lupus was replicated in a study of 1892 European-derived SLE patients and 2652 European-derived controls; the odds ratio observed was 1.22 (CI: 1.11-1.34, corrected p-value=2.59 x 10e-5).

A;G

Slightly higher risk for lupus. This finding has been replicated across several populations, but in all, the effect is fairly small.

A;A

This has been replicated across several populations, but the increase in risk for lupus is fairly small.

Source and license

Adapted from rs10516487 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.