rs1057090

A SNP in the MCPH1-AS1 gene on chromosome 8. Its most notable genotype is C;C: common in clinvar

Gene
MCPH1-AS1
Location
Chr 86,621,521 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
49%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodcommon in clinvarTypical · 0.026% of people

On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 26%
  • European ancestry (Utah)C;C 31%
  • Han Chinese (Beijing)C;C 17%
  • Japanese (Tokyo)C;C 6%
  • Yoruba (Nigeria)C;C 34%
  • African ancestry (Southwest US)C;C 32%
  • Chinese (Denver)C;C 8%
  • Gujarati IndianC;C 26%
  • Luhya (Kenya)C;C 17%
  • Mexican ancestry (Los Angeles)C;C 43%
  • Maasai (Kenya)C;C 32%
  • TuscanC;C 44%

Other MCPH1-AS1 SNPs

All MCPH1-AS1 SNPs

Notes

From SNPedia

Notes

mentioned as potentially affecting white matter volume, sample size tiny

Source and license

Adapted from rs1057090 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.