rs1058396

A SNP in the LOC105372093 gene on chromosome 18. Its most notable genotype is A;A: Jk(a-/b+) Kidd blood group, barring other variants

Gene
LOC105372093
Location
Chr 1845,739,554 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
45%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodJk(a-/b+) Kidd blood group, barring other variantsMinor · 1.018% of people
  2. A;GGoodJk(a+/b+) Kidd blood group, barring other variantsMinor · 1.044% of people
  3. G;GGoodJk(a+/b-) Kidd blood group, barring other variantsMinor · 1.038% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 18% A;G 44% G;G 38%
  • European ancestry (Utah)A;A 21% A;G 56% G;G 23%
  • Han Chinese (Beijing)A;A 26% A;G 47% G;G 28%
  • Japanese (Tokyo)A;A 25% A;G 57% G;G 19%
  • Yoruba (Nigeria)A;A 5% A;G 27% G;G 68%
  • African ancestry (Southwest US)A;A 4% A;G 44% G;G 53%
  • Chinese (Denver)A;A 39% A;G 42% G;G 19%
  • Gujarati IndianA;A 8% A;G 46% G;G 47%
  • Luhya (Kenya)A;A 7% A;G 36% G;G 57%
  • Mexican ancestry (Los Angeles)A;A 29% A;G 45% G;G 26%
  • Maasai (Kenya)A;A 8% A;G 44% G;G 47%
  • TuscanA;A 26% A;G 44% G;G 30%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs1058396, also known as c.838G>A, p.Asp280Asn and D280N, is a variant in the SLC14A1 gene on chromosome 18 that encodes the Jk(a)/Jk(b) Kidd Blood Group antigens. The rs1058396(G) allele encodes the Asp amino acid defining the Jk(a) antigen, and the (A) allele encodes the Asn defining Jk(b). Bladder Cancer Non-ABO Blood Groups

A;A

Unless there are other mitigating mutations, this genotype leads to being Kidd blood group Jk(a-/b+).

A;G

Unless there are other mitigating mutations, this genotype leads to being Kidd blood group Jk(a+/b+).

G;G

Unless there are other mitigating mutations, this genotype leads to being Kidd blood group Jk(a+/b-).

Source and license

Adapted from rs1058396 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.