rs1061325

A SNP in the CLTCL1 gene on chromosome 22. Its most notable genotype is C;C: Two copies of "farmer" CLTCL1 gene variant

Gene
CLTCL1
Location
Chr 2219,196,584 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedTwo copies of "farmer" CLTCL1 gene variantWorth knowing · 2.015% of people
  2. C;TNot ratedOne copy of "hunter-gather" CLTCL1 gene variant + one "farmer" variantWorth knowing · 2.045% of people
  3. T;TNot ratedTwo copies of "hunter-gatherer" CLTCL1 gene variantWorth knowing · 2.040% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 15% C;T 45% T;T 40%
  • European ancestry (Utah)C;C 25% C;T 57% T;T 19%
  • Han Chinese (Beijing)C;C 11% C;T 41% T;T 48%
  • Japanese (Tokyo)C;C 7% C;T 34% T;T 59%
  • Yoruba (Nigeria)C;C 3% C;T 36% T;T 61%
  • African ancestry (Southwest US)C;C 9% C;T 35% T;T 56%
  • Chinese (Denver)C;C 8% C;T 60% T;T 32%
  • Gujarati IndianC;C 41% C;T 42% T;T 18%
  • Luhya (Kenya)C;C 7% C;T 40% T;T 52%
  • Mexican ancestry (Los Angeles)C;C 14% C;T 43% T;T 43%
  • Maasai (Kenya)C;C 13% C;T 57% T;T 30%
  • TuscanC;C 30% C;T 51% T;T 19%

Other CLTCL1 SNPs

All CLTCL1 SNPs

Notes

From SNPedia

Show notes, about 140 words

Also known as M1316V or p.Met1316Val, rs1061325 represents a common variant in the clathrin heavy chain like 1 CLTCL1 gene on chromosome 22. The (T) allele is associated with the Met (M) codon, and the (C) with Val (V), as represented on the forward/plus strand. A 2019 publication gathered a fair amount of attention in the popular press by speculating that the V1316 allele has a selective advantage in processing carbohydrate-rich diets (presumably including those with lots of sugar) of farmers compared to the M1316 allele found at somewhat higher frequencies in hunter-gatherers (who theoretically consume fewer carbs). The authors suggest that heterozygotes may have a selective advantage, with M1316 homozygotes presumably most prone to developing insulin resistance on modern diets.

C;C

see text on main rs-page

C;T

see text on main rs-page

T;T

see text on main rs-page

Source and license

Adapted from rs1061325 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.