rs1061646

A SNP in the FANCA gene on chromosome 16. Its most notable genotype is G;G: 1.16x increased risk for breast cancer

Gene
FANCA
Location
Chr 1689,739,569 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
48%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableBad1.16x increased risk for breast cancerTypical · 0.022% of people
  2. A;GNot rated1.08x increased risk for breast cancerTypical · 0.043% of people
  3. A;ANot ratednormal riskTypical · 0.035% of people

SNPedia records rs1061646 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 22% A;G 43% A;A 35%
  • European ancestry (Utah)G;G 41% A;G 44% A;A 15%
  • Han Chinese (Beijing)G;G 2% A;G 42% A;A 56%
  • Japanese (Tokyo)G;G <1% A;G 29% A;A 70%
  • Yoruba (Nigeria)G;G 14% A;G 46% A;A 41%
  • African ancestry (Southwest US)G;G 33% A;G 35% A;A 32%
  • Chinese (Denver)G;G 6% A;G 42% A;A 51%
  • Gujarati IndianG;G 18% A;G 53% A;A 30%
  • Luhya (Kenya)G;G 16% A;G 48% A;A 36%
  • Mexican ancestry (Los Angeles)G;G 24% A;G 45% A;A 31%
  • Maasai (Kenya)G;G 22% A;G 53% A;A 25%
  • TuscanG;G 64% A;G 32% A;A 4%

Conditions, medicines and genes

Other FANCA SNPs

All FANCA SNPs

Notes

From SNPedia

Notes

breast cancer rs1061646 was associated with risk in the initial study (p=0.0052), and in the replication studies (p=0.032). In a combined analysis, (8,556 cases, 9,605 controls) this SNP yielded an 8% increase in risk per allele. Note that this analysis was carried out in a multi-ethnic study, and rs1061646 showed more consistent association with risk in non-Caucasian populations.

Source and license

Adapted from rs1061646 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.