rs107251

A SNP in the SIRT6 gene on chromosome 19. Its most notable genotype is C;C: common in complete genomics

Gene
SIRT6
Location
Chr 194,176,088 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
18%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodcommon in complete genomicsTypical · 0.071% of people

On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 71%
  • European ancestry (Utah)C;C 69%
  • Han Chinese (Beijing)C;C 49%
  • Japanese (Tokyo)C;C 51%
  • Yoruba (Nigeria)C;C 98%
  • African ancestry (Southwest US)C;C 83%
  • Chinese (Denver)C;C 45%
  • Gujarati IndianC;C 74%
  • Luhya (Kenya)C;C 92%
  • Mexican ancestry (Los Angeles)C;C 54%
  • Maasai (Kenya)C;C 84%
  • TuscanC;C 79%

Notes

From SNPedia

Notes

One study found that individuals with either the CC or CT genotype at rs107251 within SIRT6 displayed >5-year mean survival advantages compared to the TT genotype (5.5 and 5.9 years, respectively; q-value = 0.012).

Source and license

Adapted from rs107251 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.