rs10754558

A SNP in the NLRP3 gene on chromosome 1. Its most notable genotype is G;G: common in clinvar

Gene
NLRP3
Location
Chr 1247,448,734 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
36%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodcommon in clinvarTypical · 0.019% of people

On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 19%
  • European ancestry (Utah)G;G 15%
  • Han Chinese (Beijing)G;G 26%
  • Japanese (Tokyo)G;G 29%
  • Yoruba (Nigeria)G;G 5%

Other NLRP3 SNPs

All NLRP3 SNPs

Source and license

Adapted from rs10754558 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.