rs10761659

A SNP on chromosome 10. Its most notable genotype is A;G: 1.2x risk of Crohn's disease

Gene
None listed
Location
Chr 1062,685,804 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
50%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ABad1.5x risk of Crohn's diseaseTypical · 0.038% of people
  2. A;GMost notableBad1.2x risk of Crohn's diseaseMinor · 1.033% of people
  3. G;GGoodnormalTypical · 0.029% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 38% A;G 33% G;G 29%
  • European ancestry (Utah)A;A 16% A;G 58% G;G 27%
  • Han Chinese (Beijing)A;A 5% A;G 31% G;G 64%
  • Japanese (Tokyo)A;A 6% A;G 45% G;G 49%
  • Yoruba (Nigeria)A;A 94% A;G 6% G;G 0%
  • African ancestry (Southwest US)A;A 77% A;G 21% G;G 2%
  • Chinese (Denver)A;A 5% A;G 30% G;G 65%
  • Gujarati IndianA;A 17% A;G 38% G;G 46%
  • Luhya (Kenya)A;A 79% A;G 21% G;G 0%
  • Mexican ancestry (Los Angeles)A;A 14% A;G 43% G;G 43%
  • Maasai (Kenya)A;A 76% A;G 22% G;G 1%
  • TuscanA;A 25% A;G 49% G;G 27%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs10761659 has been reported in a large study to be associated with Crohn's disease. The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.23 (CI 1.05-1.45), and for homozygotes, 1.55 (CI 1.3-1.84).

Source and license

Adapted from rs10761659 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.