rs1080985

A SNP in the LOC107984152 gene on chromosome 22. Its most notable genotype is G;G: a common variant

Gene
LOC107984152
Location
Chr 2242,132,375 (GRCh38)
Highest magnitude
0.1Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
17%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot rateda common variantTypical · 0.1
  2. C;GNot rateda common variantTypical · 0.1
  3. C;CNot ratedHomozygous for CYP2D6 variants (non-CYP2D6*1)Typical · 0.0

SNPedia records rs1080985 on the minus strand: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Show notes, about 170 words

rs1080985 is a SNP near the CYP2D6 gene. Depending on the publication source, it may be called "-1584C/G" or "1496C>G" or the like. The wild type (normal) allele at this SNP is (C). The (G) variant indicates the presence of a non-wild type CYP2D6 variant, but it appears in many different variants so it can not be used to determine the presence of any particular variant. The rs1080985(G) allele defines the CYP2D6*2A variant, which has been reported to have relatively normal function yet in some cases may also lead to the intermediate metabolism phenotype. Please be careful when interpreting results for this SNP as it is in dbSNP and SNPedia in minus orientation where the risk allele is G, but test results are usually in plus orientation where the risk allele is C. This SNP has an ambiguous flip which can make this very confusing. Genotyping panel for assessing response to cancer chemotherapy. Replication Study to Confirm the Role of CYP2D6 Polymorphism rs1080985 on Donepezil Efficacy in Alzheimer's Disease Patients.

Source and license

Adapted from rs1080985 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.