rs10825992
A SNP on chromosome 10. Its most notable genotype is G;G: Increased high myopia risk
- Gene
- None listed
- Location
- Chr 1057,188,447 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 39%
Genotypes
As shown in 23andMe and AncestryDNA files.
- G;GMost notableBadIncreased high myopia risk
- G;TBadincreased high myopia risk
- T;TGooddecreased high myopia risk
On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 25% G;T 37% T;T 38%
- European ancestry (Utah)G;G 12% G;T 48% T;T 40%
- Han Chinese (Beijing)G;G 2% G;T 25% T;T 73%
- Japanese (Tokyo)G;G 5% G;T 19% T;T 77%
- Yoruba (Nigeria)G;G 64% G;T 32% T;T 4%
- African ancestry (Southwest US)G;G 57% G;T 38% T;T 5%
- Chinese (Denver)G;G <1% G;T 24% T;T 75%
- Gujarati IndianG;G 10% G;T 50% T;T 41%
- Luhya (Kenya)G;G 58% G;T 38% T;T 4%
- Mexican ancestry (Los Angeles)G;G 10% G;T 43% T;T 47%
- Maasai (Kenya)G;G 39% G;T 45% T;T 16%
- TuscanG;G 12% G;T 45% T;T 43%
Notes
From SNPedia
Notes
G;G
Associated with "high myopia" in French people. 46.3% of people with high myopia had G here, compared to 34.8% of people without high myopia.(table)
G;T
Associated with "high myopia" in French people. 46.3% of people with high myopia had G here, compared to 34.8% of people without high myopia.(table)
T;T
Less likely to have "high myopia" (in French people).(table)
References
Source and license
Adapted from rs10825992 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.