rs10835638

A SNP in the FSHB gene on chromosome 11. Its most notable genotype is G;G: common

Gene: FSHB
Location: Chr 1130,230,805 (GRCh38)
Highest magnitude: 0.0Typical
Tested on: 23andMe, AncestryDNA
Minor allele frequency: 9%

Genotypes

As shown in 23andMe and AncestryDNA files.

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Notes

From SNPedia

Show notes, about 190 words

rs10835638, aka c.-280G>T or −211G>T in some publications, is a SNP located in the (upstream) regulatory region of the follicle stimulating hormone FSHB gene which may influence hormone levels. A quantitative genetic association study of 550+ healthy Estonian men (average age 19) found that rs10835638 was significantly associated with serum FSH level (analysis of variance: F = 13.0, P = 0.0016, df = 1; regression testing for a linear trend: P = 0.0003). Subjects with the (G;G) genotype had higher FSH levels (3.37 +/- 1.79 IU/l, n = 423) compared with (G;T) heterozygotes (2.84 +/- 1.54 IU/l, n = 125) (p = 0.0005) or (T;T) homozygotes (2.02 +/- 0.81 IU/L, n = 6) (P = 0.031). rs10835638 was also associated with significant reduction in free testosterone index and testes volume, but increased semen volume, sex hormone-binding globulin, serum testosterone and estradiol LH and inhibin-B levels did not differ significantly between groups. {{PMID Auto |PMID=19897680 |Title=Increased Prevalance of the -211 T Allele of Follicle Stimulating Hormone (FSH) {beta} Subunit Promoter Polymorphism and Lower Serum FSH in Infertile Men |OA=1 }}

Source and license

Adapted from rs10835638 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.