rs10865331

A SNP on chromosome 2. Its most notable genotype is A;A: 1.4x higher risk for ankylosing spondylitis

Gene
None listed
Location
Chr 262,324,337 (GRCh38)
Highest magnitude
1.4Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
42%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad1.4x higher risk for ankylosing spondylitisMinor · 1.421% of people
  2. A;GBad1.2x higher risk for ankylosing spondylitisMinor · 1.248% of people
  3. G;GNot ratednormal risk ankylosing spondylitisTypical · 0.031% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 21% A;G 48% G;G 31%
  • European ancestry (Utah)A;A 6% A;G 45% G;G 49%
  • Han Chinese (Beijing)A;A 18% A;G 50% G;G 32%
  • Japanese (Tokyo)A;A 4% A;G 45% G;G 50%
  • Yoruba (Nigeria)A;A 31% A;G 49% G;G 20%
  • African ancestry (Southwest US)A;A 37% A;G 53% G;G 11%
  • Chinese (Denver)A;A 17% A;G 52% G;G 31%
  • Gujarati IndianA;A 18% A;G 48% G;G 35%
  • Luhya (Kenya)A;A 25% A;G 54% G;G 22%
  • Mexican ancestry (Los Angeles)A;A 10% A;G 45% G;G 45%
  • Maasai (Kenya)A;A 41% A;G 42% G;G 17%
  • TuscanA;A 19% A;G 51% G;G 30%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs10865331 is a SNP in chromosomal region 2p15. After initial GWAS reports linked this SNP to ankylosing spondylitis (AS), a follow-up study in 456 Spanish patients replicated the association between the rs10865331(A) allele and higher risk for AS (p = 0.039). In a 2010 report, the AA genotype was associated with 1.3x odds of ankylosing spondylitis, and the GG genotype with 0.8x odds, compared to the AG genotype.

Source and license

Adapted from rs10865331 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.