rs10883365

A SNP in the LINC01475 gene on chromosome 10. Its most notable genotype is G;G: 1.62x increased risk for developing Crohn's disease

Gene
LINC01475
Location
Chr 1099,528,007 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
48%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodNormal risk of developing Crohn's diseaseMinor · 1.028% of people
  2. A;GBad1.2x increased risk for developing Crohn's diseaseMinor · 1.550% of people
  3. G;GMost notableBad1.62x increased risk for developing Crohn's diseaseWorth knowing · 2.023% of people
  4. T;TNot ratedNo summary available.Typical · 0.00% of people

On SNPedia: (A;A), (A;G), (G;G), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 28% A;G 50% G;G 23% T;T 0%
  • European ancestry (Utah)A;A 32% A;G 45% G;G 23% T;T 0%
  • Han Chinese (Beijing)A;A 29% A;G 49% G;G 22% T;T 0%
  • Japanese (Tokyo)A;A 27% A;G 50% G;G 23% T;T 0%
  • Yoruba (Nigeria)A;A 30% A;G 51% G;G 19% T;T 0%
  • African ancestry (Southwest US)A;A 19% A;G 53% G;G 28% T;T 0%
  • Chinese (Denver)A;A 28% A;G 47% G;G 26% T;T 0%
  • Gujarati IndianA;A 36% A;G 50% G;G 15% T;T 0%
  • Luhya (Kenya)A;A 26% A;G 46% G;G 27% T;T 0%
  • Mexican ancestry (Los Angeles)A;A 38% A;G 48% G;G 14% T;T 0%
  • Maasai (Kenya)A;A 17% A;G 56% G;G 27% T;T 0%
  • TuscanA;A 23% A;G 50% G;G 28% T;T 0%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 170 words

rs10883365 has been reported in a large study to be associated with Crohn's disease. The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.2 (CI 1.03-1.39), and for homozygotes, 1.62 (CI 1.37-1.92). The association between rs10883365 and Crohn's disease was replicated in a Japanese population. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Worldwide population differentiation at disease-associated SNPs. Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes. Unbiased estimation of odds ratios: combining genomewide association scans with replication studies. Lack of association of NKX2-3, IRGM, and ATG16L1 inflammatory bowel disease susceptibility variants with celiac disease. NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients.

Source and license

Adapted from rs10883365 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.